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경희대학교의과대학 의공학교실

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학력

경희대학교 의과대학 M.D.
Rutgers University, NJ USA, 의공학 Ph.D.

 

경력

현 경희의료원 연구부 연구부장

현 경희대학교 생체의과학과 주임교수

현 경희대학교 부설 의료산업연구원 (HIRI) 원장

현 경희대학교 의공학교육센터(BEC) 소장

현 경희대학교 의과대학 의공학교실 주임교수

현 경희대학교 고황의학연구소 연구실장

현 경희의료원 의용공학과 과장

Wayne State University 조교수

Wayne State University Adjunct Faculty

Wayne State University Research Associate

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대한의용생체공학회 총무이사

대한약리학회 회원

한국바이오칩학회 회원

대한생체역학회 감사

대한생체의료학회 이사

대한 정신약물학회 이사

Frontiers in Neuroengineering Editorial Member

Neurological Research Editorial Member

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(1) 다채널 생체신호 실시간 모니터링 시스템 기반 뇌질환 진단 및 치료효과 평가 

질환 동물모델 개발 및 평가 : 11개 혈관차단법을 통한 전뇌경색 모델, 국소뇌허혈 모델
실시간 신경계 모니터링 시스템 구축 : 뇌파, 뇌혈류량, 신경전달물질 변화량 측정
주요 약물, 처치법 및 한방 침 자극 등에 의한 뇌신경 보호효과 평가

 

 

(2) CNT X-ray 진단기 개발 

치아우식 및 류마티스성 관절염 조기 진단용 CNT X-ray 진단 시스템 개발
임상시험을 통한 진단기 성능 향상
비임상시험 및 임상시험 프로토콜 개발

 

 

(3) 하이브리드 기술기반 4차원 차세대 교정치료시스템 개발

교정력 측정장치 설계 및 시제품개발
CT정보를 FEA용 모형으로 급속 변환하는 기술 개발
진단시스템 및 역 교정치료계획시스템 개발

 

 

(4) 손상조직 치료용 천연물 기반 고기능성 생체접착제의 개발

생분해성 poly L-Lactide 또는 Poly L-caprolactone을 도입하여 고탄성 접착제 물성 변화를 유도함 
경조직용 접착제로서 Hydroxy apatite를 도입함
연조직용 생체접착제의 생체친화성 확인을 위한 세포 연구, 생체적합성 및 유효성 평가를 위한 동물 연구 
경조직용 생체접착제를 이용한 치아 상아질과의 결합강도 및 생체친화성 비교연구

 

 

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나노소재기반 멀티엑스선원 및 단층합성영상 시스템 기술 개발 (지식경제부)

손상조직 치료용 천연물 기반 고기능성 생체접착제의 개발 (보건복지부)

차세대 압타머 기반 심혈관질환 조기진단 및 치료시스템 개발 (보건복지부)

나노 기반 차세대 방사선 진단기 연구단 (서울시)

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2013논문실적

1. Gyeong Bok Jung, Ji-Hye Kim, Jin Sik Burm, Hun-Kuk Park, Fabrication of chitosan-silver nanoparticle hybrid 3D porous structure as a SERS substrate for biomedical applications, Applied Surface Science, 273, 179-183, 2013.

2. Young Ju Lee, Gi-Ja Lee, Sung Wook Kang, Youjin Cheong, Hun-Kuk Park, Label-free and quantitative evaluation of cytotoxicity based on surface nanostructure and biophysical property of cells utilizing AFM, Micron 49, 54-59, 2013.

3. Gi-Ja Lee, Jae Hoon Jeong, Sora Lee, Samjin Choi, Youngmi Kim Pak, Weon Kim, Hun-Kuk Park, Quantitative and qualitative analysis of heart mitochondria for evaluating the degree of myocardial injury utilizing atomic force microscopy, Micron 44, 167-173, 2013.

4. Samjin Choi, Youjin Cheong, Jae-Ho Shin, Kyung A Kim, Jae Beum Bang, Kyung-Hyun Jin, Hun-Kuk Park, Short-term response of Mitomycin C on the human rectus muscle following strabismus surgery: Histological, ultrastructural, and biomechanical evaluation, Microscopy and Microanalysis, 19, 227-232, 2013.

5. Hyung Woo Kwak, Samjin Choi, Youjin Cheong, Jin Sik Burm, Kyung-Hyun Jin, Hun-Kuk Park, Jae-Ho Shin, Postoperative effect of radiofrequency treatments on the rabbit dermal collagen fibrillary matrix, Microscopy Research and Technique, 76, 219-224, 2013. 

2012년 논문실적

1. Lee GJ, Chae SJ, Kim SK, Lee SR, Shin JH, Kim W, Park HK, Real time dynamics of nitric oxide during cardiac ischemia-reperfusion of the rat, Sensors and Actuators B: Chemical, 161, 480-485, 2012.

2. Moon HJ, Ko WK, Han SW, Kim DS, Hwang YS, Park HK, Kwon IK, Antioxidants, like coenzyme Q10, selenite and curcumin, inhibited osteoclast differentiation by suppressing reactive oxygen species generation, Biochemical and Biophysical Research Communications, 418, 247-253, 2012.

3. Kim KS, Cho CH, Park EK, Jung MH, Yoon KS, Park HK, AFM-detected apoptotic changes in morphology and biophysical property caused by paclitaxel in Ishikawa and HeLa cells, PLos One, 7(1), e30066, 2012.

4. Shin MK, Kim KS, Ahn JJ, Kim NI, Park HK, Haw CR, Investigation of the hair of patients with scalp psoriasis using atomic force microscopy, Clin Exp Dermatol. 37(2), 156-63, 2012.

5. Kim YS, Kim KS, Han I, Kim MH, Jung MH, Park HK, Quantitative and qualitative analysis of the antifungal activity of allicin alone and in combination with antifungal drugs, PLoS One. 7(6), e38242, 2012.

6. Lim JI, Park HK, Boric acid-enhanced embedding medium for cryomicrotomy, Acta Histochemica 114, 296– 299, 2012.

7. Choi S, Joo HJ, Cheong Y, Park YK, Park HK, Effects of self-ligating brackets on the surfaces of stainless steel wires following clinical use: AFM investigation, J Microscopy 246, 53-59, 2012.

8. Cheong Y, Choi S, Kim SJ, Park HK, Nanostructural effect of acid-etching and fluoride application on human primary and permanent tooth enamels, Materials Science and Engineering C 32, 1127-1132, 2012.

9. Lim JI, Kim JH, Park HK, Artificial nerve scaffold of fascicles of poly (L-lactide) microfiber and knitted polyethylene terephthalate protector, Microelectronic Engineering 96, 6–10, 2012.

10.Lim JI, Kim JH, Park HK, The adhesive properties of prepolymerized allyl 2-cyanoacrylate/poly L-3,4-dihydroxyphenylalanine for use as bioglue, Materials Letters 81, 251–253, 2012.

11. Lim JI, Park HK, Fabrication of macroporous chitosan/poly(L-lactide) hybrid scaffolds by sodium acetate particulate-leaching method, J Porous Mater 19, 383–387, 2012.

12. Kim KS, Kim YS, Lim JI, Jung MH, Park HK. Nanoscale imaging of morphological changes of umbilical cord in pre-eclampsia, Microsc Res Tech. 75(10), 1445-51, 2012.

13. Kwon E, Choi S, Cheong Y, Park KH, Park HK, Scanning electron microscopy study of the effect of brushing time on the human tooth dentin after exposure to acidic softdrinks, Journal of Nanoscience and Nanotechnology, 12, 5199-5204, 2012.

14. Choi S, Cheong Y, Shin JH, Lee HJ, Lee GJ, Choi SK, Jin JH, Park HK, Short-term nanostructural effects of high radiofrequency treatment on the skin tissues of rabbits, Lasers Med. Sci., 27, 923-933, 2012.

15. Lim JI, Park HK, Preparation of enhanced three-dimensional porous chitosan scaffolds by acetylation and aqueous extraction, J Porous Mater 19, 537–542, 2012. 

16. Jeong KH, Lee TW, Ihm CG, Moon JY, Lee GJ, Park KH, and Lee SH, Real-time monitoring of the effects of telmisartan on angiotensin II-induced mechanical changes in live mesangial cells using atomic force microscopy. Kidney Blood Press Res., 35, 573-582, 2012.

17. Yoo SD, Choi S, Lee GJ, Chon J, Jeong YS, Park HK, Kim HS. Effects of extracorporeal shockwave therapy on nanostructural and biomechanical responses in the collagenase-induced Achilles tendinitis animal model. Lasers Med Sci, 27, 1195-1204 (2012).

18. Lee GJ, Kim SK, Kang SW, Kim OK, Chae SJ, Choi S, Shin JH, Park HK, and Chung JH, Real time measurement of myocardial oxygen dynamics during cardiac ischemia–reperfusion of rats, Analyst, 137(22), 5312-5319, 2012.

19. Choi S, Lee HJ, Cheong Y, Shin JH, Jin KH, Park HK, and Park YG, AFM study for morphological characteristics and biomechanical properties of human cataract anterior lens capsules. Scanning, 34(4), 247-256 (2012)

20.  Choi S, Park KH, Cheong Y, Moon SW, Park YG, and Park HK, Potential effects of tooth-brushing on human dentin wear following exposure to acidic soft drinks. Journal of Microscopy, 247(2), 176-185 (2012)

21. Choi S, Lee S, Cheong Y, Park KH, Park HK, and Park YG, Ultrastructural effect of self-ligating bracket materials on stainless steel and superelastic NiTi wire surfaces. Microscopy Research and Technique, 75(8), 1076-1083 (2012)

22. Kim KS, Shin MK, Kim JH, Kim MH, Haw CR, Park HK, Effects of Atopic Dermatitis on the Morphology and Water Content of Scalp Hair, Microscopy Research and Technique, 75, 620-625 (2012)

23. Kim KS, Shin MK, Park HK, Effects of Ultraviolet B Radiation on Physicochemical Properties of Human Hair Shaft, Microscopy Research and Technique, 75, 949-954 (2012).

24. Kim YS, Kim KS, Cho CH, Yoon KS, Park HK, Jung MH, Quantitative Analysis with Atomic Force Microscopy of Cisplatin induced Morphological Changes in HeLa and Ishikawa Cells, J Nippon Med Sch 79(5), 320-326, 2012.

2012년 학회실적

1. Youjin Cheong, Samjin Choi, Jae-Ho Shin, Kyung-HyunJin, and Hun-Kuk Park, Effects of RF treatments on rabbit dermal tissues. Educational Workshop for MD/DDS-PhD and Physician-Scientists, 198, January 2012.

2. Samjin Choi, Youjin Cheong, Sunghoon Lee, Joa Kyum Kim, and Hun-Kuk Park, Effects of brushing times on human dentin wear after exposure to cola drinks, World Congress 2012 Medical Physics and Biomedical Engineering. Beijing, China, TH.14/01.2P-02, May 2012.

3. Samjin Choi, Jae-Ho Shin, Youjin Cheong, Gyeong-Bok Jung, Sunghoon Lee, Joa Kyum Kim, Kyung-Hyun Jin, and Hun-Kuk Park, Biomechanical behaviors of corneo-scleral collagen cross-linking treatment on human tissues, World Congress 2012 Medical Physics and Biomedical Engineering. Beijing, China, TH.14/01.2P-03, May 2012.

4. Samjin Choi, Sunghoon Lee, Youjin Cheong, Joa Kyum Kim, Ki-Ho Park, DoYeon Kim, Young-Joo Lee, Sung Hyun Chung, Hun-Kuk Park, and Young-Guk Park, Development of 4-Dimension Hybrid Orthodontic Treatment System, 2012 KSBMB Annual Meeting, Y-70, May 2012.

5. Samjin Choi, Gyeong Bok Jung, Youjin Cheong, Jae-Ho Shin, Kyung-Hyun Jin, and Hun-Kuk Park, Ultrastructural and mechanical effects of collagen cross-linking treatment on human corneo-scleral tissues, Nanotech 2012, Santa Clara CA, USA, TH8.132, June 2012.

6. Sunghoon Lee, Samjin Choi, Youjin Cheong, Joa Kyum Kim, and Hun-Kuk Park, Ultrastructural Effects of Ligating Method Based on Initial Force Delivery Characteristics of Orthodontic NiTi Wire, In: The 10th International Nanotech Symposium & Exhibition in Korea. Seoul, Korea, August 2012.

7. G.J. Lee, S.W. Kang, O.K. Kim, S.K. Kim, J.H. Shin, H.K. Park, Simultaneous Measurement of Nitric Oxide and Oxygen Dynamics During Myocardial Ischemia Reperfusion of Rat, Nanotech 2012, Santa Clara CA, USA,  June 2012.

2012년 학술지 게재물

1. Lee GJ, Chae SJ, Kim SK, Lee SR, Shin JH, Kim W, Park HK, Real time dynamics of nitric oxide during cardiac ischemia-reperfusion of the rat, Sensors and Actuators B: Chemical, 161, 480-485, 2012.

2. Moon HJ, Ko WK, Han SW, Kim DS, Hwang YS, Park HK, Kwon IK, Antioxidants, like coenzyme Q10, selenite and curcumin, inhibited osteoclast differentiation by suppressing reactive oxygen species generation, Biochemical and Biophysical Research Communications, 418, 247-253, 2012.

3. Kim KS, Cho CH, Park EK, Jung MH, Yoon KS, Park HK, AFM-detected apoptotic changes in morphology and biophysical property caused by paclitaxel in Ishikawa and HeLa cells, PLos One, 7(1), e30066, 2012.

4. Shin MK, Kim KS, Ahn JJ, Kim NI, Park HK, Haw CR, Investigation of the hair of patients with scalp psoriasis using atomic force microscopy, Clin Exp Dermatol. 37(2), 156-63, 2012.

5. Kim YS, Kim KS, Han I, Kim MH, Jung MH, Park HK, Quantitative and qualitative analysis of the antifungal activity of allicin alone and in combination with antifungal drugs, PLoS One. 7(6), e38242, 2012.

6. Lim JI, Park HK, Boric acid-enhanced embedding medium for cryomicrotomy, Acta Histochemica 114, 296– 299, 2012.

7. Choi S, Joo HJ, Cheong Y, Park YK, Park HK, Effects of self-ligating brackets on the surfaces of stainless steel wires following clinical use: AFM investigation, J Microscopy 246, 53-59, 2012.

8. Cheong Y, Choi S, Kim SJ, Park HK, Nanostructural effect of acid-etching and fluoride application on human primary and permanent tooth enamels, Materials Science and Engineering C 32, 1127-1132, 2012.

9. Lim JI, Kim JH, Park HK, Artificial nerve scaffold of fascicles of poly (L-lactide) microfiber and knitted polyethylene terephthalate protector, Microelectronic Engineering 96, 6–10, 2012.

10. Lim JI, Kim JH, Park HK, The adhesive properties of prepolymerized allyl 2-cyanoacrylate/poly L-3,4-dihydroxyphenylalanine for use as bioglue, Materials Letters 81, 251–253, 2012.

11. Lim JI, Park HK, Fabrication of macroporous chitosan/poly(L-lactide) hybrid scaffolds by sodium acetate particulate-leaching method, J Porous Mater 19, 383–387, 2012.

12. Kim KS, Kim YS, Lim JI, Jung MH, Park HK. Nanoscale imaging of morphological changes of umbilical cord in pre-eclampsia, Microsc Res Tech. 75(10), 1445-51, 2012. 

13. Kwon E, Choi S, Cheong Y, Park KH, Park HK, Scanning electron microscopy study of the effect of brushing time on the human tooth dentin after exposure to acidic softdrinks, Journal of Nanoscience and Nanotechnology, 12, 5199-5204, 2012.

14. Choi S, Cheong Y, Shin JH, Lee HJ, Lee GJ, Choi SK, Jin JH, Park HK, Short-term nanostructural effects of high radiofrequency treatment on the skin tissues of rabbits, Lasers Med. Sci., 27, 923-933, 2012.

15. Lim JI, Park HK, Preparation of enhanced three-dimensional porous chitosan scaffolds by acetylation and aqueous extraction, J Porous Mater 19, 537–542, 2012.

16. Jeong KH, Lee TW, Ihm CG, Moon JY, Lee GJ, Park KH, and Lee SH, Real-time monitoring of the effects of telmisartan on angiotensin II-induced mechanical changes in live mesangial cells using atomic force microscopy. Kidney Blood Press Res., 35, 573-582, 2012.

17. Yoo SD, Choi S, Lee GJ, Chon J, Jeong YS, Park HK, Kim HS. Effects of extracorporeal shockwave therapy on nanostructural and biomechanical responses in the collagenase-induced Achilles tendinitis animal model. Lasers Med Sci, 27, 1195-1204 (2012).

18. Lee GJ, Kim SK, Kang SW, Kim OK, Chae SJ, Choi S, Shin JH, Park HK, and Chung JH, Real time measurement of myocardial oxygen dynamics during cardiac ischemia–reperfusion of rats, Analyst, 137(22), 5312-5319, 2012.

19. Choi S, Lee HJ, Cheong Y, Shin JH, Jin KH, Park HK, and Park YG, AFM study for morphological characteristics and biomechanical properties of human cataract anterior lens capsules. Scanning, 34(4), 247-256 (2012)

20. Choi S, Park KH, Cheong Y, Moon SW, Park YG, and Park HK, Potential effects of tooth-brushing on human dentin wear following exposure to acidic soft drinks. Journal of Microscopy, 247(2), 176-185 (2012)

21. Choi S, Lee S, Cheong Y, Park KH, Park HK, and Park YG, Ultrastructural effect of self-ligating bracket materials on stainless steel and superelastic NiTi wire surfaces. Microscopy Research and Technique, 75(8), 1076-1083 (2012)

22. Kim KS, Shin MK, Kim JH, Kim MH, Haw CR, Park HK, Effects of Atopic Dermatitis on the Morphology and Water Content of Scalp Hair, Microscopy Research and Technique, 75, 620-625 (2012)

23. Kim KS, Shin MK, Park HK, Effects of Ultraviolet B Radiation on Physicochemical Properties of Human Hair Shaft, Microscopy Research and Technique, 75, 949-954 (2012).

24. Kim YS, Kim KS, Cho CH, Yoon KS, Park HK, Jung MH, Quantitative Analysis with Atomic Force Microscopy of Cisplatin induced Morphological Changes in HeLa and Ishikawa Cells, J Nippon Med Sch 79(5), 320-326, 2012.

연구업적 – 특허(국내등록)

1.동물 모델의 이스케미아에 따른 실시간 신경계 측정 시스템, 0991548, 10-2008-0055562, 2008.06.13

2.허혈성 동물 모델 실시간 모니터링 시스템, 0991620, 10-2008-0055565, 2008.06.13   

3.류마티스 관절염 진단 장치 및 그 방법, 1055226, 10-2009-0044839, 2009.05.22    

4.치아 경조직의 탈회 감지 시스템 및 방법, 1068300, 10-2009-0044833, 2009.05.22     

5.치아우식증 분석을 위한 이미지 변환 시스템 및 그 방법, 1069026, 10-2009-004483, 2009.05.22    

6.절연 기둥을 포함하는 엑스레이 소스, 1070091, 10-2010-0114145, 2010.11.16  

7.점광원 형태의 에미터를 포함하는 엑스레이 소스, 1145531, 10-2010-0096023, 2010.10.01  

8.로컬 바이너리 피팅법을 이용한 관절 간격 측정방법, 1151155, 10-2010-0061150, 2010.06.28  

9.전기화학적 바이오 센서용 전극 및 이를 포함하는 바이오 센서, 1159012, 10-2010-0115101, 2010.11.18   

10.엑스레이 소스 어셉터 및 이를 포함하는 엑스레이 시스템, 1201092, 10-2010-0135815, 2010.12.27   

11.교정력 측정기, 1201176, 10-2011-0067553, 2011.07.07   

12.가시광선 응답형 산화티타늄 광촉매가 코팅된 자가정화 인공수정체의 제조방법, 1203793, 10-2011-0072816, 2011.07.22    

13.타이포돈트와 로드셀을 이용한 교정력 측정기, 1215735, 10-2011-0097150, 2011.09.26    

14.다중 배열 엑스레이 시스템, 1222224, 10-2011-0027203, 2011.03.25    

15.소형 엑스레이 소스를 포함하는 단층 영상 시스템, 1232421, 10-2011-0038646, 2011.04.25 

16.냉각 및 차폐 기능이 있는 엑스레이 소스, 1247453, 10-2011-0082471, 2011.08.18   

17.전열역학장치를 이용한 치아 이동의 실시간 모니터링 시스템, 1260197, 10-2012-0017698, 2012.02.21 

18.원격 제어 엑스레이 장치, 1266618, 10-2011-0050279, 2011.05.26    

19.회절 격자 기반의 엑스레이 장치, 1267615, 10-2011-0067552, 2011.07.07

국내출원

1.카테콜 기를 함유하는 아크릴산 고분자 화합물 및 시아노아크릴레이트를 포함하는 생체접착제 조성물 및 이의 제조방법, 10-2011-0098362, 2011.09.28
2.회전하는 플랫폼을 가진 단층 영상 합성 시스템, 10-2011-0112988, 2011.11.01  
3.알릴 2-시아노아크릴레이트 예비중합체, 이의 제조방법 및 상기 예비중합체를 포함하는 생체접착제 조성물, 10-2011-0115354, 2011.11.07
4.고주파를 이용하여 효과적인 주름 제거를 위한 방법과 임상 프로토콜, 10-2011-0146250, 2011.12.29  
5.L-3,4-디하이드록시페닐알라닌과 시아노아크릴레이트를 이용한 생체 접착제 및 이의 제조방법, 10-2012-0015940, 2012.02.16 
6.폴리 L-3,4-디하이드록시페닐알라닌과 시아노아크릴레이트를 포함하는 생체 접착제 및 이의 제조방법, 10-2012-0015941, 2012.02.16 
7.부정교합 모델의 유한요소해석 방법, 10-2012-0017699, 2012.02.21 
8.컴팩트형 엑스레이 제어 장치, 10-2012-0078414, 2012.07.18 
9.CT영상으로부터 치열구조의 자동추출방법, 10-2012-0082679, 2012.07.27
10. 디지털 엑스레이 소스, 10-2012-0082710, 2012.07.27  
11. 심장 허혈 및 재관류에 따른 실시간 생체신호 측정 장치, 10-2012-0089089, 2012.08.14  
12. AFM과 탐침형 센서를 이용한 세포독성의 정량적 평가시스템 및 방법, 10-2013-0012579, 2013.02.04
13. 미세유체칩을 이용한 뇌혈관모델, 10-2013-0015527, 2013.02.13  
14. 세포 기능 평가용 양방향 동시측정 시스템, 10-2013-0029410, 2013.03.19   

국제특허

1.냉각 및 차폐 기능이 있는 엑스레이 소스, PCT/KR2012/006569, WO 2013/025080, 2012.08.17
2.타이포돈트와 로드셀을 이용한 교정력 측정기, PCT/KR2012/007778, WO 2013/048124, 2012.09.26
3.알릴 2-시아노아크릴레이트 예비중합체, 이의 제조방법 및 상기 예비중합체를 포함하는 생체접착제 조성물, 2012.11.06   

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